论文部分内容阅读
目的探讨骨代谢标志物骨钙素(OC)水平与老年T2DM动脉粥样硬化的关系。方法161例老年T2DM患者分为颈动脉粥样硬化斑块组(CAS)73例、颈动脉内-中膜增厚组(CIMT增厚)52例及颈动脉内-中膜正常组(CIMT正常)34例。比较各组OC等水平。结果 CAS组OC水平低于CIMT增厚组及CIMT正常组(P<0.05)。相关分析结果显示,OC与HbA1c及高血压水平呈负相关(r=-0.454、-0.067,P=0.006、0.036)。结论OS水平降低可能是老年T2DM患者CAS程度的危险因素。
Objective To investigate the relationship between osteocalcin (OC) level and atherosclerosis in elderly patients with T2DM. Methods One hundred and sixty-one elderly patients with T2DM were divided into three groups: carotid atherosclerotic plaque group (CAS), carotid arterial intima-media thickness (CIMT) thickened group, carotid arterial intima-media thickness 34 cases. Compare the OC and other levels of each group. Results The level of OC in CAS group was lower than that in CIMT group and CIMT group (P <0.05). Correlation analysis showed that OC was negatively correlated with HbA1c and hypertension (r = -0.454, -0.067, P = 0.006,0.036). Conclusion The decrease of OS level may be the risk factor of CAS in elderly patients with T2DM.