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目的 研究几丁聚糖对大鼠急性腹膜炎的治疗和术后肠粘连的预防作用。方法 4个月龄大鼠 2 0 0只制成急性腹膜炎和肠粘连动物模型。用 1 %的几丁聚糖作腹腔灌注 ,以生理盐水、 1 %醋酸和甲硝唑分别作对照 ,观察大鼠的死亡率、两周后存活动物的肠粘连程度和血清可溶性白细胞介素 - 2受体水平。结果 几丁聚糖显著降低大鼠的死亡率和粘连等级 (P <0 0 5)。在不同时间血清可溶性白细胞介素 - 2受体显著低于各对照组 (P <0 0 5)。结论 1 %几丁聚糖对治疗急性腹膜炎和预防肠粘连有显著的作用
Objective To study the preventive effect of chitosan on acute peritonitis and intestinal adhesion in rats. Methods Two hundred and four rats of 4 months old were made into animal models of acute peritonitis and intestinal adhesion. 1% chitosan was intraperitoneal perfusion, saline, 1% acetic acid and metronidazole were used as controls, the mortality of rats were observed, two weeks later the survival of intestinal adhesion and serum soluble interleukin - 2 receptor level. Results Chitosan significantly reduced the mortality and adhesion level in rats (P <0.05). Serum soluble interleukin - 2 receptor was significantly lower than that of control group at different time points (P <0.05). Conclusion 1% chitosan has a significant effect on the treatment of acute peritonitis and prevention of intestinal adhesion