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用六条健康犬进行了头孢噻甲羧肟的药代动力学研究及组织浓度测定。剂量20mg/kg(肌注及静注)。血药浓度及组织浓度测定采用微生物法。结果显示静脉及肌注后的血药浓度一时间曲线分别符合二室及一室开放模型。静往后即刻的平均血药浓度为167.28±15.73ug/ml,肌注0.85小时后的峰浓度为54.86±
Six healthy dogs were tested for the pharmacokinetics and tissue concentration of ceftazidime. Dose 20mg / kg (intramuscular and intravenous). Blood concentration and tissue concentration using the microbiological method. The results showed that intravenous and intramuscular injection of plasma concentrations of a time curve were consistent with two-compartment and one-compartment open model. The average plasma concentration immediately after the static 167.28 ± 15.73ug / ml, intramuscular injection of 0.85 hours after the peak concentration of 54.86 ±