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NK细胞是不同于T ,B淋巴细胞而能够直接杀伤靶细胞效应的一个特殊淋巴细胞系 ,由骨髓造血干细胞发育而来 ,其分化过程受多种细胞因子的调节 ,其中IL 2作用CD34+造血干细胞产生的NK可能是NK前体细胞 ,具有部分的杀伤活性 ;IL 12是效应最强的NK细胞激活因子 ,但是 ,单独促进生成NK细胞的分化能力很弱 ;IL 15存在于骨髓中 ,可能是NK细胞分化成熟的天然调节因子 ;IL 7可直接诱导NK细胞产生LAK活性 ,其诱导产生的NK细胞比IL 2诱导的NK细胞更为不成熟
NK cells are different from T, B lymphocytes and can directly kill the target cell effect of a special lymphocyte lineage, bone marrow hematopoietic stem cells from the development of its differentiation is regulated by a variety of cytokines, including IL 2 CD34 + hematopoietic stem cells NK produced may be NK precursor cells, with partial killing activity; IL 12 is the most potent NK cell activator, however, alone to promote the generation of NK cells differentiation is weak; IL 15 is present in the bone marrow may be NK cells differentiate into matured natural regulators; IL 7 directly induces NK cell production of LAK activity, which induces more immature NK cells than IL 2 -induced NK cells