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二组用维持量治疗的心脏病患者服用7种不同的商品地高辛片剂(每片0.25毫克),每组各服4种,其中吸收率最高的一种二组都服用,以作比较。服用剂量在整个疗程中不变,每种片剂服2周后采血样用放射免疫测定法测定血浆中地高辛浓度,并用美国药典(1970版)方法测定片剂的溶解速度(用600毫升蒸馏水,篮子转速120次/分,隔一定时间抽样,用滤孔为0.45微米的滤器过滤,用萤光法测定含量)。所得数据经统计学处理发现,在相同的剂量时,不同的商品片剂所达到的血浆浓度有显著差别(P<0.1),并与各种片剂的溶解速度有相应关系。以吸收最佳的片剂服药二周后血浆地高辛浓度为100,则最差的片剂仅为72。又以吸收最佳的片剂进行溶解速度试验,在第1小时中溶解的地高辛达到标示量的100%,而最差的片剂仅为48%。地高辛片剂吸收的显著差别与片剂的溶解速度有一
Two groups of cardioplegic patients treated with maintenance doses of seven different commercial digoxin tablets (0.25 mg per tablet), four in each group, with one of the two groups having the highest absorption rates, were compared for comparison . Dosing was unchanged throughout the course of treatment. Blood samples were taken 2 weeks after each tablet for radioimmunoassay. Plasma digoxin concentration was determined by the U.S. Pharmacopeia (1970 version) method using 600 ml Distilled water, the basket speed of 120 beats / min, sampling at regular intervals, with a 0.45-micron filter filter, using the fluorescence method to determine the content). The data obtained were statistically analyzed and found to be significantly different (P <0.1) from the plasma levels achieved by the different commercial tablets at the same dose, and correlated with the dissolution rate of various tablets. In order to absorb the best tablet after two weeks of plasma digoxin concentration of 100, the worst tablet is only 72. Dissolution rates were also tested with the best absorbed tablets, with digoxin dissolved in 100% of the indicated amount in the first hour compared to only 48% of the worst tablet. The significant difference between digoxin tablet absorption and tablet dissolution rate is one