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目的:研制调胃承气汤证兔动物模型。方法:将60只日本大耳白兔随机分为正常对照组、调胃模型组、模型治疗组和模型验证组。在次碳酸铋、禁水的基础上,用大肠杆菌内毒素攻毒,观察家兔的体温、腹围、二便等一般状态、检测白细胞数量和NO含量、脏器的病理形态学变化。结果:模型组家兔体温升高,腹围增大,WBC和NO含量明显增高(P(0.01),部分脏器出现了明显的病理改变。治疗组和验证组则有明显的改善。结论:采用这种多因素联合造模方法研制出的调胃承气汤证兔动物模型,在症状、体征、实验室指标及病理改变上与调胃承气汤证有较强的相关性,可以认为该造模方法是比较成功的。
Objective: To develop a rabbit model of Tiaowei Chengqi Decoction. METHODS: Sixty Japanese white rabbits were randomly divided into normal control group, gastric adjustment model group, model treatment group, and model validation group. On the basis of bismuth subcarbonate and water-inhibition, E. coli endotoxin was used to challenge the general state of rabbit’s body temperature, abdominal circumference, and two stools, and the white blood cell count, NO content, and pathological changes of organs were observed. RESULTS: Rabbits in the model group had elevated body temperature, increased abdominal circumference, and increased WBC and NO levels (P <0.01). Some organs showed obvious pathological changes. The treatment group and the validation group showed significant improvement. The animal model of Tiaowei Chengqi Decoction that was developed using this multi-factor combination modeling method has strong correlation with symptoms of symptoms, signs, laboratory indicators, and pathological changes, and may be considered to be related to Tiaowei Chengqi Decoction. The modeling method is relatively successful.