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目的:观察复方苦参注射液联合化疗治疗晚期胃癌临床疗效。方法:将152例胃癌患者随机分为治疗组与对照组,治疗组77例患者,采用复方苦参注射液联合化疗;对照组75例患者,采用单纯化疗。结果:经治疗,治疗组治疗总缓解率为67.5%,明显高于对照组的43.2%,比较差异有统计学意义(P<0.05);治疗组生活质量好转率为74.0%,明显优于对照组的38.7%,比较差异有统计学意义(P<0.01);治疗组白细胞减少、胃肠道反应、神经毒性、肝功能异常等不良反应发生率均明显低于对照组,差异有统计学意义(P均<0.05),而脱发、血小板减少等发生率比较差异均无统计学意义(P>0.05)。结论:复方苦参注射液可显著提高晚期胃癌的化疗效果,降低毒副反应发生率,值得临床推广应用。
Objective: To observe the curative effect of Compound Kushen Injection and Chemotherapy in the treatment of advanced gastric cancer. Methods: 152 patients with gastric cancer were randomly divided into treatment group and control group. 77 patients in the treatment group were treated with compound matrine injection combined with chemotherapy. In the control group, 75 patients were treated with chemotherapy alone. Results: After treatment, the total remission rate of the treatment group was 67.5%, which was significantly higher than that of the control group (43.2%, P <0.05), and the improvement rate of the quality of life in the treatment group was 74.0% (P <0.01). The incidences of adverse reactions such as leukopenia, gastrointestinal reaction, neurotoxicity and abnormal liver function in the treatment group were significantly lower than those in the control group (P <0.01), the difference was statistically significant (P <0.05), while there was no significant difference in incidence of hair loss and thrombocytopenia (P> 0.05). Conclusion: Compound Kushen injection can significantly improve the chemotherapy effect of advanced gastric cancer and reduce the incidence of toxic reactions, worthy of clinical application.