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目的:研究中国成年人群受教育水平与代谢综合征(MS)发病风险之间的关系.方法:以中国心血管病流行病学多中心协作研究和中国心血管健康多中心合作研究为基线,于2007-2008年进行随访.调查人口学特征、社会经济状况、生活方式以及进行体格检查、实验室测定等,最终将12 784例35~74岁研究对象纳入分析.按照受教育水平将研究对象分成未上学、小学、初中、高中/中专和大专及以上5组,应用二分类logistic回归模型分析受教育水平与MS发病风险、基线吸烟和饮酒习惯之间的关系.结果:平均随访8.1年,2 760例发生MS.多因素调整后,与未上学者相比,小学、初中、高中/中专和大专及以上者的MS发病风险逐渐降低,RR(95% CI)分别为0.93 (0.79~1.10)、0.97(0.81~1.16)、0.72(0.59~0.87)和0.57(0.45~0.72), P趋势<0.0001;大专及以上学历者有吸烟、嗜烟酒习惯的OR(95% CI)分别为0.25(0.19~0.34)和0.34(0.22~0.52),有统计学意义.结论:中国成年人群中受教育程度低者的MS发病风险高,更有可能嗜烟酒,是心血管病的高危人群.“,”Objective: To assess the relationship of educational level and the incidence of metabolic syndrome (MS) among Chinese adults aged 35~74 years in a prospective cohort study. Methods: At baseline, participants were investigated regarding demographic characteristics, socioeconomic status, lifestyle risk factors and other variables of MS in the China Multicenter Collaborative Study of Cardiovascular Epidemiology (1998) and China Cardiovascular Health Study (2000-2001). The final analysis included 12 784 participants (6 179 men and 6 605 women) who were followed up in 2007-2008. Educational level was classiifed into 5 categories: illiteracy (n=1 241, 9.71%), primary(n=3 814 , 29.83%), junior high (n=3 759, 29.40%), senior high (n=2 728, 21.34%) and college or above (n=1 242 , 9.72%). Binary logistic regression analyses were used to measure the association between educational level and the incidence of MS, as well as smoking and drinking. Results: A total of 2 760 incident MS were identiifed after an average of 8.1 years follow up. After adjustment for multi-variables, an inverse gradient in the incidence of MS was showed through categories of education. Compared with the illiteracy group, the RR (95% CI) of incident MS for persons with primary school, junior high, senior high and college or above education were 0.93 (0.79~1.10), 0.97 (0.81~1.16), 0.72 (0.59~0.87) and 0.57 (0.45~0.72),respectively, (P for trend<0.0001). Persons in college or above education status were less likely smoking (OR=0.25, 95%CI: 0.19~0.34) or tobacco and alcohol addiction (OR=0.34, 95% CI: 0.22~0.52), P <0.05.Conclusion: Lower education is associated with higher risk of incident MS in Chinese adults. Lower educated personsare more likely addicted to tobacco and alcohol, which might partially explain the susceptibility of metabolic syndromeamong adults with lower education.