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目的:探讨扩张型心肌病患者血浆趋化素水平变化。方法:用酶联免疫吸附法测定扩张型心肌病患者和对照组血浆趋化素水平,免疫发光夹心法测定C反应蛋白水平。结果:扩张型心肌病患者血浆趋化素和C反应蛋白水平较对照组明显升高,差异均有统计学意义(均P<0.05)。血浆趋化素水平与C反应蛋白、左室舒张末期内径显著正相关,与左室射血分数显著负相关。结论:扩张型心肌病患者血浆趋化素水平升高,可能参与扩张型心肌病的慢性炎症反应过程,并与受损心功能密切相关。
Objective: To investigate the changes of plasma chemokines in patients with dilated cardiomyopathy. Methods: The levels of chemokines in patients with dilated cardiomyopathy and control group were measured by enzyme - linked immunosorbent assay (ELISA) and the level of C - reactive protein by immunofluorescence sandwich method. Results: The levels of chemokine and C-reactive protein in patients with dilated cardiomyopathy were significantly higher than those in the control group (all P <0.05). There was a significant positive correlation between plasma chemokine levels and C-reactive protein and left ventricular end-diastolic diameter, and negatively correlated with left ventricular ejection fraction. Conclusions: Patients with dilated cardiomyopathy have elevated levels of chemokines, which may be involved in the process of chronic inflammatory reaction of dilated cardiomyopathy and are closely related to impaired cardiac function.