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目的观察胎盘多肽注射液联合化疗药物治疗结直肠癌根治术后的临床疗效和安全性。方法选择结直肠癌根治术后化疗患者80例,随机分为研究组和对照组各40例。两组均采用m FOLFOX6方案化疗,研究组在化疗开始时应用胎盘多肽8 ml,静脉滴注,连用14天,所有患者完成6个周期的化疗,观察两组临床疗效和化疗引起的毒副作用。结果 1研究组总有效率为45.0%,对照组总有效率为42.5%,两组总有效率比较无统计学差异(P>0.05)。2两组主要不良反应为恶心、呕吐、腹泻、口腔黏膜炎、外周神经毒性和肝功能损害等。研究组恶心、呕吐、口腔黏膜炎、外周神经毒性发生率显著低于对照组(P<0.05)。3治疗前两组白细胞、血小板、血红蛋白水平比较无统计学差异(P>0.05),治疗后两组白细胞、血小板、血红蛋白水平显著降低,研究组白细胞水平显著高于对照组(P<0.05)。结论胎盘多肽注射液联合化疗治疗结直肠癌根治术后患者,可以有效降低化疗的不良反应,提高患者生活质量。
Objective To observe the clinical efficacy and safety of placental peptide injection combined with chemotherapy in the treatment of colorectal cancer after radical operation. Methods Eighty patients with chemoradiotherapy after radical resection of colorectal cancer were randomly divided into study group (40 cases) and control group (40 cases). Both groups were treated with m FOLFOX6 regimen. The study group applied 8 ml of placental polypeptide at the beginning of chemotherapy and intravenously for 14 days. All patients completed 6 cycles of chemotherapy. The clinical efficacy and chemotherapy-induced side effects were observed in both groups. Results 1 The total effective rate was 45.0% in the study group and 42.5% in the control group. There was no significant difference in the total effective rate between the two groups (P> 0.05). 2 The two major adverse reactions were nausea, vomiting, diarrhea, oral mucositis, peripheral neurotoxicity and liver dysfunction. The study group nausea, vomiting, oral mucositis, peripheral neurotoxicity was significantly lower than the control group (P <0.05). There were no significant differences in leukocyte, platelet and hemoglobin levels between the two groups before treatment (P> 0.05). The levels of leukocyte, platelet and hemoglobin in the two groups were significantly decreased after treatment. The levels of leukocytes in the study group were significantly higher than those in the control group (P <0.05). Conclusion The combination of placental peptide injection and chemotherapy in patients with colorectal cancer after radical operation can effectively reduce the adverse reactions of chemotherapy and improve the quality of life of patients.