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以往研究表明Wilms瘤中WT1基因在体内具有抑癌基因的特性,它在粒细胞性白血病和慢粒急变期病人的白血病细胞中高度表达,其表达的程度与预后及治疗效果密切相关。本文旨在检测WT1基因在白血病细胞系增殖和分化中的作用。
Previous studies have shown that WT1 gene in Wilms tumor has the characteristics of tumor suppressor gene in vivo. It is highly expressed in leukemia cells of patients with granulocytic leukemia and chronic myeloid blast crisis. Its degree of expression is closely related to the prognosis and therapeutic effect. This article aims to examine the role of WT1 gene in proliferation and differentiation of leukemia cell lines.