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目的探讨乳癖康合剂(由柴胡、茯苓、三棱、莪术等组成)对乳腺增生病大鼠的治疗效果及作用机理。方法采用苯甲酸雌二醇联合黄体酮造模,用乳癖康合剂治疗30d,观察大鼠乳腺增生的程度以及血清性激素水平的变化和其对乳腺组织血管内皮生长因子(VEGF)、微血管密度(MVD)表达的影响。结果乳癖康合剂能够降低乳腺增生病大鼠血清雌二醇(E2)、垂体促乳素(PRL)及促卵泡成熟激素(FSH)含量,升高孕激素(P)的含量。结论乳癖康合剂可通过调节乳腺增生病大鼠的性激素水平、影响VEGF的活性、抑制腺体新生血管的形成、改善腺体的微循环而逆转乳腺腺体的增生。
Objective To investigate the therapeutic effect and mechanism of Rupikang mixture (composed of Radix Bupleuri, Radix Puerariae, Trigonellae, Curcuma and others) on rats with hyperplasia of mammary glands. Methods The model of oestradiol benzoate combined with progesterone was used. After 30 days of treatment with Rupikang Mixture, the degree of hyperplasia of mammary glands and changes of serum sex hormone levels were observed, and its effects on vascular endothelial growth factor (VEGF) and microvessel density of mammary tissue ( The effect of MVD) expression. RESULTS: Rupikang Mixture can reduce serum estradiol (E2), pituitary prolactin (PRL) and follicle-stimulating hormone (FSH) levels in rats with hyperplasia of mammary glands and increase progesterone (P) content. Conclusion Ruyukang Mixture can reverse the hyperplasia of mammary glands by regulating the levels of sex hormones, affecting the activity of VEGF, inhibiting the formation of glandular neovascularization, and improving the microcirculation of glands in rats with mammary gland hyperplasia.