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目的探讨汉族和维吾尔族正常出生体重儿及低出生体重儿孕烷受体(PXR)水平及相关性。方法收集2014年1-10月乌鲁木齐市妇幼保健院和自治区人民医院的汉、维吾尔族正常和低出生体重新生儿脐带血,采用酶联免疫法检测孕烷受体水平。结果汉、维吾尔族低出生体重儿脐血中PXR水平均高于正常出生体重组,且维吾尔族低出生体重儿与正常出生体重儿PXR水平差异有统计学意义(P<0.05);汉族正常体重儿和低出生体重儿PXR水平均高于维吾尔族,差异有统计学意义(P<0.05)。结论孕烷受体水平高低与汉、维吾尔族新生儿出生体重有一定关联,但其机制需要进一步探讨。
Objective To investigate the levels and correlation of pregnane receptor (PXR) in normal and low birth weight infants of Han and Uighur ethnic groups. Methods Umbilical cord blood was collected from normal and low birth weight neonates of Han and Uighur ethnic groups in Urumqi MCH Hospital of Xinjiang Uygur Autonomous Region and People’s Hospital of Xinjiang Uygur Autonomous Region from January to October 2014. The levels of pregnane receptor were detected by enzyme-linked immunosorbent assay. Results The levels of PXR in cord blood of Han and Uighur low birth weight infants were higher than those of normal birth weight group, and there was significant difference in PXR between Uighur low birth weight infants and normal birth weight infants (P <0.05) The level of PXR in children and low birth weight children were higher than Uygur nationality (P <0.05). Conclusion The level of PRRS is related to the birth weight of neonates in Han and Uygur nationality. However, its mechanism needs to be further explored.