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目的了解平湖地区孕早期妇女TORCH〔包括弓形体(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)、单纯疱疹病毒Ⅰ型、Ⅱ型(HSV-Ⅰ、HSV-Ⅱ)〕的感染状况。方法应用酶联免疫吸附试验(ELISA)检测1593例孕早期妇女血清中TORCH-IgM及IgG抗体水平,并比较结果。结果 TOX-IgM、RV-IgM、CMV-IgM、HSVⅠ-IgM、HSVⅡ-IgM的阳性率分别为0.25%、0.31%、0.38%、2.01%、1.51%,HSVⅠ-IgM的阳性率最高,差异有统计学意义(χ2=47.52,P<0.05)。TOX-IgG、RV-IgG、CMV-IgG、HSVⅠ-IgG、HSVⅡ-IgG的阳性率分别为2.32%、85.81%、98.12%、92.59%、9.73%,CMV-IgG的阳性率最高,差异有统计学意义(χ2=5880.61,P<0.05)。HSVⅠ-IgM抗体在秋冬季节的阳性率高于春夏季节(χ2=14.28,P<0.05),HSVⅡ-IgM抗体的阳性率在秋冬季节也高于春夏季节(χ2=12.29,P<0.05)。结论平湖地区孕早期妇女存在一定的TORCH阳性率,TORCH感染是不良妊娠结局的重要危险因素,因此在早孕期或孕前进行TORCH检测非常必要。
Objective To understand the infection status of TORCH (including TOX, RV, CMV, HSV-Ⅰ, HSV-Ⅱ) in the first trimester of Pinghu region. . Methods Serum levels of TORCH-IgM and IgG in 1593 pregnant women were detected by enzyme-linked immunosorbent assay (ELISA), and the results were compared. Results The positive rates of TOX-IgM, RV-IgM, CMV-IgM, HSVⅠ-IgM and HSVⅡ-IgM were 0.25%, 0.31%, 0.38%, 2.01% and 1.51% Statistical significance (χ2 = 47.52, P <0.05). The positive rates of CMV-IgG, TOX-IgG, RV-IgG, CMV-IgG, HSVⅠ-IgG and HSVⅡ-IgG were 2.32%, 85.81%, 98.12%, 92.59% and 9.73% Significance (χ2 = 5880.61, P <0.05). The positive rate of HSVⅠ-IgM antibody in autumn and winter was higher than that in spring and summer (χ2 = 14.28, P <0.05). The positive rate of HSVⅡ-IgM was also higher than that in spring and summer (χ2 = 12.29, P <0.05) . Conclusion TORCH positive rate exists in pregnant women in Pinghu region. TORCH infection is an important risk factor of adverse pregnancy outcome. Therefore, it is necessary to detect TORCH in early pregnancy or before pregnancy.