用免疫放射法（ＩＲＭＡ）测定了３７８例各种甲状腺疾病及非甲状腺疾病（ＮＴＩ）患者血清ＴＳＨ以及Ｔ_３、Ｔ_４和ＦＴ_４水平。结果：未治疗或症状未控制的甲亢患者血清ＴＳＨ明显低于对照组，甲亢治愈者则恢复正常。甲减者ＴＳＨ变化与其临床表现相一致。在碘缺乏病区ＴＳＨ－ＩＲＭＡ能较Ｔ_３、Ｔ_４更好的反映居民的碘营养状况。在ＮＴＩ时虽有Ｔ_３、Ｔ_４的改变，但ＴＳＨ－ＩＲＭＡ和ＦＴ_４结果大多为正常。本文表明ＴＳＨ－ＩＲＭＡ在评估甲状腺功能状态时有较好的敏感性及特异性。 Serum levels of TSH, T_3, T_4 and FT_4 in 378 patients with thyroid disease and non-thyroid disease (NTI) were measured by immunoradiometric assay (IRMA). Results: Serum TSH in untreated or uncontrolled patients with hyperthyroidism was significantly lower than that in control group, and those cured by hyperthyroidism returned to normal. TSH hypothyroidism changes consistent with its clinical manifestations. In iodine deficiency ward TSH-IRMA better than T_3, T_4 reflect the residents of iodine nutrition. Although there are changes of T_3 and T_4 in NTI, the results of TSH-IRMA and FT_4 are mostly normal. This article shows that TSH-IRMA in the assessment of thyroid function has better sensitivity and specificity.