D-青霉胺是治疗Vilson氏病的首选药物。然而,该药可引起许多副反应,约50%的用药患者出现副反应,其中1/3因此而中止治疗。Wilson氏病患者中因青霉胺副作用致死的约占10%。近年来,锌已被成功地用于治疗Wilson氏病。口服锌能抑制肠道对铜的吸收,诱导机体呈缺铜状态。虽然,后者是引起正常人和非Wilson氏病患者的主要副反应,但至今尚未发现锌治疗Wilson氏病引起的副反应。过去,口服锌 D-penicillamine is the drug of choice for the treatment of Vilson’s disease. However, the drug can cause a number of side effects, with about 50% of the treated patients having side effects, of which 1/3 discontinue treatment. Wilson’s disease in patients with penicillamine side effects caused by about 10% of deaths. In recent years, zinc has been successfully used to treat Wilson’s disease. Oral zinc can inhibit the intestinal absorption of copper, induced body was copper deficiency state. Although the latter is a major side effect of normal and non-Wilson’s disease patients, no side effects have been found with zinc in the treatment of Wilson’s disease. In the past, oral zinc