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目的：探讨和研究中老年急性高原反应（ＡＭＳ）有效的药物防治。方法：对平原急进海拔５ ４００ｍ 的中老年人随机分为口服复方６５４—２（ｎ＝ １５）、复方党参（ｎ＝ １２）和空白对照（ｎ＝ １２）。上高原服药后随访进入３ ８００ｍ 、４ ２００ｍ 和５ ４００ｍ 高原时的ＡＭＳ情况，同时测血压，在返回３ ８００ｍ 时检测心电图、血液动力学。结果：与对照组比较，在４ ２００ｍ以下，两组药物对ＡＭＳ均有较好的预防效果（Ｐ＜ ０．０５和Ｐ＜ ０．０１），在５ ４００ｍ 时，复方６５４—２ 对降低ＡＭＳ的反应率，对减轻反应程度更显著（Ｐ＜ ０．０５ 和Ｐ＜ ０．００１），复方党参不显著（Ｐ＞ ０．０５）。结论：两种药物预防中老年ＡＭＳ均有较好的效果，在５ ４００ｍ 特高海拔对于降低ＡＭＳ的反应率和反应程度，以及ＰＡＷＰ、ＴＰＲ、ＨＯＩ，提高ＶＰＥ、ＳＶＬ、ＢＶ和稳定血压等，复方６５４—２ 明显优于复方党参。二者合用，可能是选择防治中老年人ＡＭＳ有效药物途径。
Objective: To explore and study the effective drug control of Acute Alveolar Reaction in Middle-aged and Aged Patients. Methods: The elderly aged 5 500 m above sea level were randomly divided into oral compound 654-2 (n = 15), Codonopsis (n = 12) and blank control (n = 12). The patients were followed up for 3 800 m, 4 200 m and 5 400 m altitude AMS, and blood pressure was measured at the same time. The electrocardiogram and hemodynamics were detected at 3 800 m. Results: Compared with the control group, both groups had better preventive effect on AMS at 4 200 m (P <0.05 and P <0.01). At 5 400 m, compound 654-2 decreased AMS (P <0.05 and P <0.001), and Codonopsis prescription was not significant (P> 0.05). CONCLUSION: Both drugs have good effect on prevention of AMS in middle-aged and elderly people. At 5 400 m altitude, the response rate and response to AMS reduction, PAWP, TPR, HOI, VPE, SVL, BV and stable blood pressure are all improved. Compound 654-2 is significantly better than compound Codonopsis. The combination of the two may be an effective drug option for the prevention and treatment of AMS in the elderly.