ObjeCtive:To explore the effect of Gushen tablet(固肾片,GST)In reducing the relapseof chidren’s nephrotic syndrome and the possible mechanism of drugs used.Methods:Fifty Children withprimary nephrotic syndrome who had been induced and alleviated with regular glucocorticoid(GC)wererandomly divided into two groups:the GST group used GST and standard middle-long term course of GC,and the control group adopted standard middle-long term course of GC and immunoinhibitory or immuno-modulatory agents for treatment.The 0.5,1 and 2 years after the treatment the relapse episodes,time forurinary protein negative conversion after relapse,the episodes of patient’s infection and relapse after infec-tion were evaluated.Before and after treatment the plasma cortisol and T lymphocyte subpopulation weredetermined.Results:The relapse rate of GST group:the rates after 0.5,1,2 years were 20.0％,30.0％and 40.9％,and the frequent relapse rate were 0,6.7％ and 9.2％ respectively,which were lower thanthose of control group(60. ObjeCtive: To explore the effect of Gushen tablet (GST) In reducing the relapse of chidren’s nephrotic syndrome and the possible mechanism of drugs used. Methods: Fifty Children with primary nephrotic syndrome who had been induced and alleviated with regular glucocorticoid (GC) wererandomly divided into two groups: the GST group used GST and standard middle-long term course of GC, and the control group adopted standard middle-long term course of GC and immunoinhibitory or immuno-modulatory agents for treatment.The 0.5,1 and 2 years after the treatment of the relapse episodes, time for urinary protein negative conversion after relapse, the episodes of patient’s infection and relapse after ingestion of animals were. ago and after treatment the plasma cortisol and T lymphocyte subpopulation were confirmed. Results: The relapse rate of GST group: the rates after 0.5,1,2 years were 20.0%, 30.0% and 40.9%, and the frequent relapse rate were 0,6.7% and 9.2% respectively, which were lower th anthose of control group (60.