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H_2-受体拮抗剂(H_2RAs)-属于最安全的一类药物,这类药物的应用相当广泛,但其不良药物反应的报道很少。有报道应用 H_2RAs 后会产生不良反应,如恶心、便秘、腹泻、头痛和皮疹,但进一步详细观察,这些反应与服用安慰剂者相似。应用H_2RAs 出现 CNS 不良反应的患者,多半是肝、肾功能不全的患者。西咪替丁对 CNS 毒性比其它 H_2RAs 要大。大剂量和长时间应用西咪替丁可引起男性患者的乳腺增生和阳萎,但在少数危重病人中这不是一个重要问题。
H 2 -receptor antagonists (H 2 RAs) - belong to the safest category of drugs, these drugs are widely used, but few reports of adverse drug reactions. H 2 RAs have been reported to produce adverse reactions such as nausea, constipation, diarrhea, headaches and rashes. However, these responses were similar to placebo in further detail. Patients with H 2 RAs that have adverse reactions to CNS are mostly liver and kidney insufficiency patients. Cimetidine is more toxic to CNS than other H 2 RAs. High doses and long-term use of cimetidine can cause breast hyperplasia and impotence in male patients, but this is not an important issue in a few critically ill patients.