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目的:探讨雷帕霉素联合紫杉醇对子宫内膜癌STAT3表达的影响及其临床意义。方法:选取我院收治的子宫内膜癌患者90例,随机分为对照组及实验组,对照组采用常规化疗治疗,实验组采用雷帕霉素联合紫杉醇化疗治疗。观察并比较两组患者治疗前后细胞生长抑制率以及干扰素、生长因子、白细胞介素及STAT3水平的变化情况。结果:与治疗前比较,两组患者治疗后细胞生长抑制率、生长因子、白细胞介素及STAT3表达水平均降低,而干扰素水平升高,差异具有统计学意义(P<0.05);与对照组比较,实验组患者治疗后细胞生长抑制率、生长因子、白细胞介素及STAT3表达水平较低,而干扰素水平较高,差异具有统计学意义(P<0.05)。结论:雷帕霉素联合紫杉醇可改善机体免疫功能活性,增强肿瘤细胞免疫活性,阻断细胞恶性增殖有丝分裂进程,提高吞噬细胞对肿瘤细胞杀伤性,临床疗效较化疗优异,可作为临床有效治疗方案,并具有重要意义。
Objective: To investigate the effect of rapamycin combined with paclitaxel on STAT3 expression in endometrial carcinoma and its clinical significance. Methods: 90 patients with endometrial cancer admitted to our hospital were randomly divided into control group and experimental group. The control group was treated with conventional chemotherapy. The experimental group was treated with rapamycin plus paclitaxel. The changes of cell growth inhibition, interferon, growth factor, interleukin and STAT3 before and after treatment were observed and compared between two groups. Results: Compared with those before treatment, the cell growth inhibition rate, growth factor, interleukin and STAT3 expression decreased and the interferon level increased, the difference was statistically significant (P <0.05). Compared with the control group Compared with the control group, the growth inhibition rate, growth factors, interleukin and STAT3 expression in the experimental group were lower and the interferon levels were higher, the difference was statistically significant (P <0.05). Conclusion: Rapamycin combined with paclitaxel can improve the immunological function, enhance the immunological activity of tumor cells, block the malignant proliferation of mitosis and increase the cytotoxicity of phagocytes to tumor cells, which is more effective than chemotherapy and can be used as a clinically effective treatment , And is of great significance.