论文部分内容阅读
目的:观察中西医结合治疗偏头痛的疗效及对血清一氧化氮(NO)、血管内皮素-1(ET-1)的影响。方法:将临床确诊的71例偏头痛患者随机分为中西医结合组35例和西药组36例。中西医结合组给予头痛Ⅰ号方加减,同时口服盐酸洛美利嗪。西药组仅服用盐酸洛美利嗪。分别观察治疗前及治疗后4周、12周患者的头痛指数及血清NO、ET-1含量变化。结果:2组治疗后4周、12周外周静脉血ET-1含量均有不同程度下降,与治疗前比较,差异均有显著性意义(P<0.05);2组治疗后组间比较,差异无显著性意义(P>0.05)。2组治疗后4周、12周外周静脉血NO含量均有不同程度下降,与治疗前比较,差异均有显著性意义(P<0.05);2组治疗后组间比较,差异无显著性意义(P>0.05)。中西医结合组治愈率、总有效率分别为88.57%、94.29%,西药组治愈率、总有效率分别为66.67%、86.11%,2组治愈率比较,差异有显著性意义(P<0.05),而总有效率比较,差异无显著性意义(P>0.05)。结论:头痛Ⅰ号方合盐酸洛美利嗪能有效地防治偏头痛及降低血清NO和ET-1浓度,其临床疗效优于盐酸洛美利嗪,中西医结合治疗偏头痛更有效。
Objective: To observe the curative effect of migraine treated by integrated traditional Chinese and western medicine and its effect on serum nitric oxide (NO) and endothelin-1 (ET-1). Methods: The clinical diagnosis of 71 migraine patients were randomly divided into 35 cases of Integrative Medicine Group and 36 cases of Western medicine group. Integrative Medicine Group headache Ⅰ No. 1 addition and subtraction, while oral Lomerizine hydrochloride. Western medicine group taking only Lomerizine hydrochloride. The changes of headache index, serum NO and ET-1 levels before and after 4 and 12 weeks of treatment were observed. Results: The levels of ET-1 in peripheral venous blood of 4 weeks and 12 weeks after treatment decreased to different extents in both groups, with significant difference compared with those before treatment (P <0.05). There was no significant difference between the two groups No significant (P> 0.05). The content of NO in the peripheral venous blood of the two groups after 4 and 12 weeks of treatment all decreased to different extents, compared with those before treatment, the difference was significant (P <0.05). There was no significant difference in the two groups after treatment (P> 0.05). The cure rate and total effective rate of TCM combined with western medicine group were 88.57% and 94.29%, respectively. The cure rate and total effective rate of western medicine group were 66.67% and 86.11% respectively. There was significant difference between the two groups (P <0.05) , While the total effective rate, the difference was not significant (P> 0.05). Conclusion: Headache Ⅰ combined with Lomerizine hydrochloride can effectively prevent migraine and reduce serum NO and ET-1 concentrations, the clinical efficacy is superior to Lomerizine hydrochloride, the combination of traditional Chinese and Western medicine treatment of migraine more effective.