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目的探讨维生素C对131I治疗分化型甲状腺癌发生放射性口腔炎或唾液腺炎的预防作用。方法 88例分化型甲状腺癌患者随机分为A组30例、B组32例与C组26例,3组均给予131I单次剂量30mCi治疗,A组于服药后2h,B组于服药后24h开始服用维生素C片10mg/次,3次/d,连续6d,2次治疗间隔3～6个月,C组服药后不用维生素C片;比较3组放射性口腔炎或唾液腺炎发生率。结果 A,B组放射性口腔炎或唾液腺炎发生率低于C组(P<0.05);A组与B组比较差异无统计学意义(P>0.05)。结论行131I治疗分化型甲状腺癌后2h和24h给予维生素C片均可有效降低放射性口腔炎或唾液腺炎的发生率。
Objective To investigate the preventive effect of vitamin C on radiation-induced stomatitis or salivary gland inflammation in 131I-treated differentiated thyroid cancer. Methods A total of 88 patients with differentiated thyroid cancer were randomly divided into group A (n = 30), group B (n = 32) and group C (n = 26). All three groups received 131I single dose 30 mCi. Start taking vitamin C tablets 10mg / time, 3 times / d, continuous 6d, 2 times treatment interval of 3 to 6 months, C group after taking vitamin C tablets; comparison 3 groups of radiation stomatitis or salivary gland inflammation incidence. Results The incidence of radiation stomatitis and salivary gland in group A and group B was lower than that in group C (P <0.05). There was no significant difference between group A and group B (P> 0.05). Conclusion 131I treatment of differentiated thyroid cancer 2h and 24h after administration of vitamin C tablets can effectively reduce the incidence of radiation stomatitis or salivary gland inflammation.