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有关肾脏维生素D代谢的调节问题有不同意见。甲状旁腺激素作为钙调节的唯一重要因素的概念已被否认。有证据说明,在生理状态下,哺乳、生长期时,可见到血中1,25(OH)_2D_3浓度增加。近来动物实验发现,催乳素和生长激素能刺激1,25(OH)_2D_3产生,提示这些垂体激素可能是肾脏维生素D的重要调节剂。为证明这些激素在人类有类似作用,作者通过放射受体测定法,测定不同人体分组循环中1,25(OH)_2D_3浓度进行分析研究。 Ⅰ组20名正常人(11男9女,平均年龄
There are different opinions on the regulation of vitamin D metabolism in the kidneys. The concept of parathyroid hormone as the only important factor in calcium regulation has been denied. There is evidence that in the physiological state, breast-feeding, growth period, we can see the blood 1,25 (OH) _2D_3 concentration increased. Recent animal experiments found that prolactin and growth hormone can stimulate 1,25 (OH) _2D_3 production, suggesting that these pituitary hormones may be an important regulator of kidney vitamin D. To demonstrate that these hormones have similar effects in humans, the authors determined the concentrations of 1,25 (OH) _2D_3 in different human groups by radioimmunoassay. Group Ⅰ 20 normal people (11 males and 9 females, mean age