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【目的】探讨家庭作坊空气有毒物质存在的苯系物对其家庭中儿童免疫功能影响情况,为建立预防措施提供理论依据。【方法】对2009年5月-2011年11月在本地区经营3年以上的家庭作坊进行空气中苯系物的监测,同时对其家庭中75例儿童血清球蛋白、唾液溶菌酶及唾液中分泌型SIgA检测。并在该地区随机抽取50名无类似家庭作坊背景的儿童作为对照组。统计两组儿童患病情况。【结果】监测组与对照组比较,IgG、唾液溶菌酶水平无明显变化(P>0.05);监测组IgM、IgA水平、SIgA总体水平低于对照组,IgE高于对照组,喘息性支气管炎患病率增多(均P<0.01);监测组总患病频率增多,无统计学意义(P>0.05)。【结论】家庭作坊空气污染物质可导致儿童的血清免疫球蛋白总体水平、非特异性免疫力(SIgA水平)下降。测定IgE水平可作为大气污染引起过敏反应人群的早期敏感效应指标。
【Objective】 The purpose of this study is to investigate the influence of benzene series substances in air toxic substances in family workshops on the immune function of children in their families and provide a theoretical basis for the establishment of preventive measures. 【Method】 From May 2009 to November 2011, the home-based workshops operating in the region for more than 3 years were used to monitor the content of benzene compounds in the air. Meanwhile, 75 children in their families were monitored for serum globulin, salivary lysozyme and saliva Secreted SIgA assay. And randomly selected 50 children without similar family background in the area as the control group. Statistics of two groups of children’s illness. 【Results】 There was no significant difference in the levels of IgG and salivary lysozyme between the monitoring group and the control group (P> 0.05). The levels of IgM and IgA in the monitoring group and the overall level of SIgA in the monitoring group were lower than those in the control group. IgE was higher in the control group and asthmatic bronchitis The prevalence rate increased (all P <0.01). The total frequency of disease in the monitoring group increased, with no statistical significance (P> 0.05). 【Conclusion】 Air pollution substances in home-based workshops can lead to the overall level of serum immunoglobulin in children and the decrease of nonspecific immunity (SIgA level). Determination of IgE levels can be used as an indicator of early-stage allergic response to air pollution in allergic populations.