2000年5月以来,我们用氟喹诺酮类药物治疗腹泻合并呕吐患者1000例,疗效较好。现报告如下。 临床资料:本组男640例,女360例;年龄18～60岁。均经大便常规检查诊断为急性肠炎或菌痢,均有不同程度的腹泻及明显的呕吐症状。入院后给予不同剂量的氟喹诺酮类药物,包括环丙沙星、洛美沙星、氟罗沙星、氧氟沙星,部分患者同时给予胃粘膜保护剂,但均未加用止吐药。治疗后,显效(呕吐及恶心症状消失)814例,有效(呕吐症状消失,仍有恶心不适感)147例,无效39例。 讨论:氟喹诺酮类药物因有明显的胃肠道副反应,故一般不作为腹泻伴呕吐患者的首选药物,以免加重其呕吐症状。本 Since May 2000, we treated fluoroquinolones with diarrhea and vomiting in 1000 patients, the effect is better. The report is as follows. Clinical data: The group of male 640 cases, 360 females; aged 18 to 60 years. All stool routine examination diagnosed as acute enteritis or bacillary dysentery, have varying degrees of diarrhea and vomiting symptoms. After admission, different doses of fluoroquinolones were given, including ciprofloxacin, lomefloxacin, fleroxacin and ofloxacin. Some patients also received gastric mucosal protective agent, but no antiemetic drugs were added. After treatment, markedly (vomiting and nausea symptoms disappeared) 814 cases, effective (vomiting disappeared, there are still discomfort nausea) 147 cases, 39 cases ineffective. Discussion: Fluoroquinolones because of obvious gastrointestinal side effects, it is generally not as the preferred drug for patients with diarrhea and vomiting, so as not to aggravate the symptoms of vomiting. this