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在脑血管病引起的脑损伤中有许多细胞因子参与,而白细胞介素6(interleukin-6,IL-6)被认为在中枢神经系统中具有神经保护和神经营养作用,其重要性倍受关注。对于急性脑血管病外周血中IL-6变化的研究报告较多,但国内外有关脑出血急性期脑脊液(cerebrospinal fluid,CSF)中IL-6变化研究都较少[1,2],而对可溶性IL-6受体(solubleinterleukin-6 receptor,sIL-6R)的研究更少。我们对脑出血急性期CSF中SIL-6R含量进行了测定,以探讨其与脑出血继发性脑损伤程度的关系。
There are many cytokines involved in cerebrovascular disease-induced brain injury, whereas interleukin-6 (IL-6) is thought to have neuroprotective and neurotrophic effects in the central nervous system and its importance pays close attention . There are many reports on the changes of IL-6 in peripheral blood of patients with acute cerebrovascular disease. However, few studies have been done on IL-6 in cerebrospinal fluid (CSF) at home and abroad [1,2] Fewer studies have investigated the soluble interleukin-6 receptor (sIL-6R). We measured the content of SIL-6R in the CSF of acute cerebral hemorrhage in order to investigate its relationship with the degree of secondary brain injury after intracerebral hemorrhage.