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目的对比临床药师干预前后医院肿瘤科抗肿瘤中成药应用情况,评价其使用的合理性,观察临床药师干预的效果。方法调查医院肿瘤科2013年1~6月(干预前)和2014年1~6月(干预后)出院病历中抗肿瘤中成药用药金额、用药频度及临床用药情况,并各抽取180份,调查比较干预前后抗肿瘤中成药的合理性情况。结果干预前后抗肿瘤中成药物用药金额分别为200.97万元和189.42万元,占同期全科用药总金额的比例分别为17.99%和17.11%,人均药费分别是5051.28和4596.26元。干预前后不合理率分别为38.89%和8.33%,干预后不合理率显著低于干预前(P<0.05)。不合理用药主要为超适应证用药、用法用量不适宜、更换药物不适宜、联合用药不适宜等。结论通过临床药师的干预,肿瘤科抗肿瘤中成药用药金额略有下降,不合理用药现象显著减少,医院合理用药的水平得到提高。
Objective To compare the clinical application of anti-tumor proprietary Chinese medicines in oncology departments before and after the intervention of clinical pharmacists to evaluate the rationality of their use and to observe the effect of clinical pharmacists intervention. Methods A total of 180 cases of anti-tumor proprietary Chinese medicines, frequency of drug use and clinical medication were collected from January to June 2013 (before intervention) and January to June 2014 (after intervention) in oncology department of the hospital from January 2013 to June 2013, Investigate the rationality of anti-tumor proprietary Chinese medicines before and after the intervention. Results Before and after the intervention, the amounts of anti-tumor drugs used in medicine were respectively RMB 2,009,700 and RMB 1,984,200, accounting for 17.99% and 17.11% of the total amount of all-departmental medicines during the same period. The per capita drug costs were 5051.28 and 4596.26 yuan respectively. Before and after the intervention, the unreasonable rates were 38.89% and 8.33% respectively, and the unreasonable rate after intervention was significantly lower than before intervention (P <0.05). Irrational use of drugs mainly for indications, usage dosage inappropriate, the replacement of drugs is not appropriate, combined with medication inappropriate. Conclusion With the intervention of clinical pharmacists, the amount of anti-tumor proprietary Chinese medicine in oncology decreased slightly, the phenomenon of irrational use of drugs decreased significantly, and the rational use of drugs in hospitals was improved.