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目的探讨在胃癌发生过程中凋亡相关基因程序性细胞死亡因子10(programmed cell death factor 10,PDCD10)的表达及其临床病理学意义。方法采用SP免疫组织化学方法检测26例正常胃粘膜,22例慢性萎缩性胃炎伴肠上皮化生及66例胃癌组织标本中PDCD10基因的表达,分析其与临床病理学参数之间的关系。结果正常胃粘膜、萎缩性胃炎伴肠上皮化生及胃癌组织中PDCD10表达阳性率分别为11.5%、31.8%和63.6%,呈现上调趋势。相关分析表明,PDCD10的表达上调与肿瘤分化程度及转移密切相关(P<0.05),而与性别、年龄及肿瘤生长部位无关(P>0.05)。结论胃癌组织中PDCD10表达较正常胃粘膜、萎缩性胃炎伴肠上皮化生明显上调,其表达程度与胃癌的分化程度及侵袭转移相关。
Objective To investigate the expression of apoptosis-related gene programmed cell death factor 10 (PDCD10) and its clinicopathological significance in the pathogenesis of gastric cancer. Methods SPCD immunohistochemical method was used to detect the expression of PDCD10 gene in 26 cases of normal gastric mucosa, 22 cases of chronic atrophic gastritis with intestinal metaplasia and 66 cases of gastric carcinomas. The relationship between the expression of PDCD10 gene and clinical pathological parameters was analyzed. Results The positive rates of PDCD10 in normal gastric mucosa, atrophic gastritis with intestinal metaplasia and gastric cancer tissues were 11.5%, 31.8% and 63.6%, respectively, showing an upward trend. Correlation analysis showed that upregulation of PDCD10 was closely related to tumor differentiation and metastasis (P <0.05), but not to gender, age and tumor growth site (P> 0.05). Conclusion The expression of PDCD10 in gastric cancer tissues is significantly upregulated compared with normal gastric mucosa and atrophic gastritis with intestinal metaplasia. The expression of PDCD10 is correlated with the differentiation and invasion and metastasis of gastric cancer.