目的:探讨乙肝疫苗免疫后无(低)应答儿童接种不同类型乙肝疫苗的再免疫效果。方法:将乙肝疫苗免疫后无(低)应答儿童400例随机分为汉逊组和酵母组各200例,汉逊组接种国产10μg汉逊乙肝疫苗,酵母组接种进口10μg重组酵母乙肝疫苗,疫苗接种前及完成再免疫第3剂疫苗后1个月采集静脉血5 mL,采用放射免疫法(RIA)进行HBsAb定量检测,对两组接种有效应答率进行比较。结果:酵母组再免疫有效应答率为83.5%,高于汉逊组的65.5%,两组比较差异有统计学意义(χ2=17.055,P<0.05)。结论:对于乙肝疫苗无(低)应答儿童再次免疫接种时,可考虑优先选择进口重组酵母乙肝疫苗进行接种。 Objective: To investigate the re-immunization effect of vaccinating children with different types of hepatitis B vaccine without (low) response to hepatitis B vaccine. Methods: 400 children without (low) response to hepatitis B vaccine were randomly divided into Hansen group and yeast group 200 cases each. Hansen group was vaccinated domestic 10μg Hansen’s hepatitis B vaccine. The yeast group was inoculated with 10μg recombinant yeast hepatitis B vaccine and vaccine Before inoculation and complete re-immunization of the third dose of vaccine one month after the collection of venous blood 5 mL, radioimmunoassay (RIA) HBsAb quantitative detection of vaccination effective response rate of the two groups were compared. Results: The effective rate of re-immunization in yeast group was 83.5%, which was higher than that in Hanson group (65.5%). There was significant difference between the two groups (χ2 = 17.055, P <0.05). Conclusion: In the case of no immunization (low response) hepatitis B vaccine, immunization should be given priority to import recombinant hepatitis B vaccine for vaccination.