腕管综合征由Cannon等(1946)与Brain等(1947)报告以来,受到各家的注意,这种综合征大多伴发于各种的全身性疾病,而原因不明的家族内发病的病例极为罕见.非特异性家族性腕管综合征自Zabriskie(1935)首先报导以来,见于文献的仅欧美7篇报告10个家族,日本迄今未有报导.作者报告在一个家族的三代中发现4例腕管综合征患者,并复习文献共11个家族的特征为:1.本综合征的男女比为 Carpal tunnel syndrome has been noticed by Cannon et al. (1946) and Brain et al. (1947), and most of these syndromes are associated with various systemic diseases. The incidence of carpal tunnel syndrome is extremely high in families with unknown causes Nonspecific familial carpal tunnel syndrome Since the first report by Zabriskie (1935), only 10 reports from 10 families in Europe and the United States have been reported in the literature and so far have not been reported in Japan. The authors report that in the three generations of a family, four cases of carpal tunnels Syndrome patients, and review the literature a total of 11 families are characterized by: 1. The syndrome of male to female ratio