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目的探讨左炔诺孕酮宫内缓释系统(曼月乐)治疗子宫肌瘤合并月经过多的临床疗效。方法选取惠东县妇幼保健院就诊的子宫肌瘤伴月经过多,且有保留子宫愿望的患者68例,于月经周期第5~7天放置曼月乐。置入后1、3、6、12个月分别对患者进行随访,记录治疗前后月经量、血红蛋白、子宫体积、肌瘤直径、性激素变化及不良反应的发生率。结果置入曼月乐后第1、3、6、12个月,与放置前比较患者月经量减少、血红蛋白升高、子宫体积和肌瘤直径均缩小,差异有统计学意义(P<0.05),性激素变化差异无统计学意义(P>0.05)。结论宫内放置曼月乐可有效改善患者月经过多的症状,纠正贫血并使瘤体缩小,效果显著,适合临床推广及进一步深入研究。
Objective To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (Mirena) in the treatment of uterine fibroids combined with menorrhagia. Methods Huidong County MCH hospital treatment of uterine fibroids with menorrhagia, and there are 68 cases of patients with uterine reservation, placed in the menstrual cycle, 5 to 7 days of Mirena. Patients were followed up 1, 3, 6 and 12 months after implantation. The menstrual flow, hemoglobin, uterine volume, fibroids diameter, sex hormones and the incidence of adverse reactions before and after treatment were recorded. Results The patients were placed in the 1st, 3rd, 6th and 12th months after Mirena. The patients’ menstrual volume, hemoglobin, uterine volume and myoma size were decreased compared with those before placement (P <0.05) There was no significant difference in sex hormones (P> 0.05). Conclusion Intrauterine Mirena can effectively improve the symptoms of menorrhagia, correct anemia and shrink the tumor, the effect is significant, suitable for clinical promotion and further study.