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目的探讨联合检测血清氨基末端脑利钠肽前体(NT-proBNP)和血清肌钙蛋白(cTnI)水平在毛细支气管炎心肌损伤诊断中的应用价值。方法选取2013年8月~2014年10月在该院因毛细支气管炎住院的患儿46例为毛细支气管炎组,于急性期及恢复期检测血清NT-proBNP和cTnI水平;另选取正常儿童32例为对照组,检测其NT-proBNP和cTnI水平,并对两组检测结果进行比较分析。结果毛细支气管炎组急性期血清NT-proBNP和cTnI水平最高,恢复期NT-proBNP和cTnI水平均下降,但仍高于对照组(P均<0.05),急性期血清NT-proBNP与cTnI呈直线正相关(r=0.725,P<0.05)。结论对毛细支气管炎患儿进行NT-proBNP和cTnI联合检测,并动态观察其变化,能够尽早发现心肌损伤,指导临床治疗。
Objective To investigate the value of combined detection of serum NT-proBNP and cTnI levels in the diagnosis of myocardial injury in patients with bronchiolitis. Methods 46 children with bronchiolitis hospitalized for bronchiolitis in our hospital from August 2013 to October 2014 were selected as bronchiolitis group. Serum levels of NT-proBNP and cTnI were detected in acute phase and convalescent phase. The normal children 32 Cases as a control group, detection of NT-proBNP and cTnI levels, and the two test results were compared. Results Serum levels of NT-proBNP and cTnI were the highest in patients with bronchiolitis, and NT-proBNP and cTnI in convalescent patients were lower than those in control group (all P <0.05) Positive correlation (r = 0.725, P <0.05). Conclusions The combined detection of NT-proBNP and cTnI in children with bronchiolitis and the dynamic observation of the changes can find myocardial injury as soon as possible and guide the clinical treatment.