目前认为在免疫口服脊髓灰质炎疫苗(OPV)之前先免疫2次脊髓灰质炎灭活疫苗(IPV)可降低OPV相关麻痹性脊髓灰质炎的危险性。本文旨在通过三种不同的OPV-IPV序贯免疫程序以及OPV、IPV单独免疫来比较诱导粘膜免疫力及体液免疫应答的差异。将510名刚出生的婴儿随机分为5组,除两组单独免疫IPV或OPV外,另三 It is currently thought that immunization of two poliomyelitis inactivated vaccines (IPVs) prior to immunization with oral polio vaccine (OPV) may reduce the risk of OPV-related paralytic poliomyelitis. This article aims to compare differences in mucosal immunity and humoral immune response by three different OPV-IPV sequential immunization programs and OPV, IPV immunization alone. 510 newborn infants were randomly divided into five groups, with the exception of two groups of IPV or OPV alone immune, the other three