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目的了解2010~2012年惠安县疾病预防控制中心结核门诊涂阳肺结核患者二线抗结核药物(secondline antituberculosis durgs,SLD)使用情况,为该县制定合理使用SLD提供参考资料。方法应用自行设计的《惠安县登记治疗肺结核患者信息调查表》,根据2010~2012年惠安县疾病预防控制中心涂阳结核病患者病案资料进行回顾性调查,对患者基本情况、SLD使用情况及影响因素进行分析。结果初治患者741例,复治患者116例,使用SLD肺结核患者治疗成功率为79.88%,未使用SLD肺结核患者治疗成功率为87.15%,两者的差异有统计学意义(P<0.01);影响SLD使用的因素为X线有无空洞、治疗分类、病变部位涉及肺野严重程度和性别(均有P<0.05)。结论涂阳肺结核患者在未进行药敏试验或者结果未报告之前,应该选择标准的化疗方案进行治疗,避免不规范使用二线抗结核药物(SLD)。
Objective To understand the use of second-line antituberculosis durgs (SLD) in tuberculosis clinics of the Huian Center for Disease Control and Prevention from 2010 to 2012 in order to provide references for the county to make rational use of SLD. Methods A self-designed questionnaire about registered TB patients in Huian County was designed. According to the medical records of smear-positive TB patients in Huian County Center for Disease Control and Prevention from 2010 to 2012, a retrospective study was conducted on the basic information of the patients, the use of SLD and its influencing factors Analyze. Results There were 741 untreated patients and 116 retreatment patients. The success rate of treatment with SLD pulmonary tuberculosis was 79.88%, and that of non - SLD tuberculosis patients was 87.15%. The difference was statistically significant (P <0.01). Factors affecting the use of SLD X-ray is void, treatment classification, lesions involving lung field severity and gender (both P <0.05). Conclusion Patients with smear positive pulmonary tuberculosis should be treated with standard chemotherapeutic regimens without prior drug susceptibility testing or with no reported results, to avoid the non-standard use of second-line anti-tuberculosis drugs (SLDs).