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目的:探讨子宫纤维瘤病的临床病理学特点、免疫表型和鉴别诊断。方法:对1例子宫纤维瘤病进行组织学和免疫组织化学观察,并复习文献。结果:巨检肿瘤呈结节状,边界欠清,切面灰白色,质嫩。镜检肿瘤由梭形细胞和胶原纤维组成,呈束状、条带状交错排列,向周围组织浸润。瘤细胞Vimentin阳性,SMA多数细胞阳性,Desmin、H-caldesmen和Calponin细胞均阴性。结论:子宫纤维瘤病主要依靠组织病理学诊断,形态上应注意与平滑肌瘤、腺肌瘤、纤维肉瘤、血管周上皮样细胞肿瘤、平滑肌肉瘤、子宫内膜间质肉瘤等病变进行鉴别。
Objective: To investigate the clinicopathological features, immunophenotypes and differential diagnosis of uterine fibromatosis. Methods: A case of uterine fibromatosis histological and immunohistochemical observation, and review the literature. Results: Giant tumor was nodular, border less clear, gray-white section, quality tender. Microscopic examination of tumor cells by the spindle cells and collagen fibers, was bundles, staggered stripes, to the surrounding tissue infiltration. The tumor cells were Vimentin positive, SMA majority of cells positive, Desmin, H-caldesmen and Calponin cells were negative. Conclusion: Uterine fibromatosis mainly relies on histopathological diagnosis. Morphology should be distinguished from leiomyoma, adenomyoma, fibrosarcoma, perivascular neoplasm tumor, leiomyosarcoma and endometrial stromal sarcoma.