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目的观察抗抑郁治疗对不稳定型心绞痛伴抑郁患者的临床疗效。方法采用 Zung 抑郁自评量表及汉密顿抑郁量表对230例不稳定型心绞痛(unstable angina pectoris,UAP)患者进行筛查,其中有110例合并抑郁。将该110例作为研究对象,随机分为抗郁治疗组和对照组各55例,治疗组在常规心绞痛治疗基础上予心理治疗及加服抗抑郁药氟西汀20 mg/d,共8周;对照组只给予单纯常规心脏药物治疗。结果治疗组心肌缺血明显改善,心绞痛缓解及心电图改善与对照组比较,差异有显著性意义(P<0.05)。结论抗抑郁治疗能明显改善UAP 伴抑郁患者的近期预后。
Objective To observe the clinical effect of antidepressant on patients with unstable angina pectoris and depression. Methods Twenty-two patients with unstable angina pectoris (UAP) were screened using the Zung Self-rating Depression Scale and the Hamilton Depression Scale, 110 of whom had depression. The 110 patients were randomly divided into anti-depression treatment group and control group of 55 cases, the treatment group on the basis of conventional angina pectoris and psychotherapy plus antidepressant fluoxetine 20 mg / d for a total of 8 weeks The control group only given simple conventional cardiac drug therapy. Results The myocardial ischemia in the treatment group was significantly improved, angina pectoris relief and ECG improvement compared with the control group, the difference was significant (P <0.05). Conclusions Antidepressant treatment can significantly improve the short-term prognosis of patients with UAP accompanied by depression.