血管支架介入术由于其微创性和高效性已经成为目前治疗由血管狭窄所引发的冠心病的主要治疗手段,但支架内再狭窄却是影响支架远期效果的最大障碍,严重制约了其实际疗效。首先从支架内再狭窄的形成机制出发,从固体力学角度回顾力学环境对再狭窄的影响,并主要阐述近年来支架在圆直、锥形、分叉、弯曲4种不同形状血管内扩张的研究进展,特别是从支架扩张对血管应力及血管形状的改变与再狭窄的相关关系方面进行综述。最后,针对不同血管形状对支架扩张的影响,提出一个旨在提高支架扩张性能及减少支架内再狭窄的血管支架多目标优化设计方法。 Due to its minimal invasiveness and high efficiency, stenting has become the main treatment for coronary heart disease caused by vascular stenosis. However, in-stent restenosis is the biggest obstacle to the long-term effect of stent, which severely restricts its actuality Efficacy. First of all, based on the mechanism of in-stent restenosis, the effect of mechanical environment on restenosis was reviewed from the point of view of solid mechanics. In the last few years, the study of stent dilatation in four different shapes of straight, tapered, bifurcated and curved In particular, advances in scaffold dilatation on vascular stress and vascular shape changes and restenosis were reviewed. Finally, according to the influence of different vessel shape on the stent dilatation, a multi-objective optimization design method of the stent is proposed to improve the stent dilatation and reduce the in-stent restenosis.