本文采用薄层扫描法,测定了牛磺酸的不同剂型给药后血药浓度的变化情况。实验结果表明,牛磺酸在家兔体内的药物动力学特征属于二室模型。静脉注射给药,其生物半衰期t_(1/2d)=t_(1/2e)=38s,可见其生物处置过程极快;肌肉注射给药吸收良好,与静脉注射比较具有维持时间长的优点;口服吸收不规则,且吸收量少。作者认为,肌肉注射牛磺酸为最佳给药途径。 In this paper, the change of plasma concentration of different taurine doses was determined by thin-layer scanning. The experimental results show that the pharmacokinetics of taurine in rabbits belongs to the two-compartment model. Intravenous injection, its biological half-life t_(1/2d) = t_(1/2e) = 38s, it can be seen that its biological disposal process is very fast; good absorption by intramuscular injection, compared with intravenous injection has the advantage of maintaining a long time; Irregular oral absorption and low absorption. The authors believe that intramuscular injection of taurine is the best route of administration.