败血症性休克常伴发DIC，主要是由于凝血系统激活产生大量凝血酶和纤维蛋白之故。凝血系统的激活相应伴发抗凝系统的激活。ATⅢ是凝血瀑布系统的强抑制剂，在肝脏中合成，钝化凝血酶，抑制多种血清蛋白酶，包括IXa、Xa、XIa、XHa因子、胞质素、血管舒缓素和胰蛋白酶等。AT因DIC Septic shock is often accompanied by DIC, mainly due to the activation of the coagulation system to produce large amounts of thrombin and fibrin. The activation of the coagulation system is accompanied by the activation of the anticoagulation system. ATⅢ is a potent inhibitor of clotting cascade system. It synthesizes and inactivates thrombin in the liver and inhibits a variety of serum proteases, including IXa, Xa, XIa, XHa, cytokines, kallikrein and trypsin. AT due DIC