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作者前曾报道,在几例伴有腹泻的结缔组织疾病患者的小肠大肠粘膜活检中见有嗜酸性细胞和肥大细胞浸润。本文描述10例隐窝周围嗜酸细胞性小肠结肠炎的临床表现和形态学特征,提供了炎症浸润致腹泻的证据。病例和方法:常规对腹泻患者检查中,10例内镜示正常粘膜像,而上、下消化道活检标本光镜下特征为:a)上皮结构保存,无溃疡、糜烂或隐窝脓肿;b)隐窝附近粘膜深部有以嗜酸性细胞为主的浸润,电镜下见肥大细胞浸润;c)在较严重病例,邻近的粘膜肌层平滑肌细胞有嗜酸性细胞浸润。并无上皮下胶原层增厚和固有层的表层炎性细胞浸润。诊断后平均随访36
The authors previously reported infiltration of eosinophils and mast cells in the large intestinal mucosal biopsies of several patients with connective tissue disease associated with diarrhea. This article describes the clinical and morphological features of 10 cases of cryptococcal enterocolitis, providing evidence of inflammatory infiltration-induced diarrhea. Cases and Methods: Conventional examination of diarrhea patients, 10 cases of endoscopic normal mucosa, while the upper and lower digestive tract biopsy specimens were characterized by a) epithelial structure preservation, no ulceration, erosion or crypt abscess; b ) There is eosinophil-based infiltration in the deep mucosa near the crypt, and mast cell infiltration under electron microscopy. C) In more severe cases, adjacent mucosal smooth muscle cells have eosinophil infiltration. No epithelial collagen layer thickening and lamina propria inflammatory cell infiltration. Follow up on average after diagnosis