胆囊收缩素(CCK)是一种肽类激素,在消化道、中枢和外周神经系统都有分布。它在神经元内合成,在突触小泡内储存和释放,可能是一种神经介质或神经激素,在神经调节中起重要作用。 用猪、猫和豚鼠的胰腺进行细胞免疫化学的实验证明,对于CCK特异抗血清显示免疫反应的神经,出现在胰岛和神经节两个不同的部位。在胰岛和神经节周围有神经未稍所形成的串珠状物出现。说明胰岛有CCK神经支配。 用色谱法以及放射免疫测定,显示有多种分子 Cholecystokinin (CCK) is a peptide hormone found in the digestive tract, central and peripheral nervous systems. It is synthesized in neurons and stored and released in synaptic vesicles. It may be a neurotransmitter or neurohormonal and plays an important role in neuromodulation. Experiments on immunocytochemistry in the pancreas of pigs, cats, and guinea pigs have shown that nerves that show an immune response to CCK-specific antisera appear at two different sites in the islets and ganglia. There are beads around the islets and ganglions that are not formed by the nerves. This shows that islets have CCK innervation. Chromatography and radioimmunoassay showed a variety of molecules