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近年来,环孢素A(Cyclosprin A,CsA)除用于治疗红斑性狼疮、类风湿性关节炎等疾病外,亦试用于治疗原发性肾小球肾炎,并取得较好的疗效. 药理作用机理CsA系真菌产生的一种由11种氨基酸组成的环形多肽.它具有特异性抑制辅助性T细胞的效应和毒效T细胞的产生,但对抑制性T细胞活性无影响.即不影响抑制性T细胞的增殖.CsA对T细胞的抑制作用较硫唑嘌呤强三倍,且对人或动物均不引起骨髓抑制. CsA治疗肾小球肾炎的作用机理,至今尚未明确.肾小球肾炎发病大多数与循环免疫复合物形成或抗肾小球基膜(GBM)抗体的形成等有密切关系,CsA作为一种免疫抑制剂,选择性作用于辅助性T
In recent years, Cyclosprin A (CsA) is also used to treat primary glomerulonephritis and achieve better therapeutic effects besides being used for the treatment of diseases such as lupus erythematosus and rheumatoid arthritis. Mechanism of action CsA is a fungal ring produced by the 11 kinds of amino acids ring polypeptide. It has a specific inhibitory effect of helper T cells and toxic T cells, but has no effect on inhibitory T cell activity. Inhibit the proliferation of T cells.CsA T cell inhibitory effect of three times stronger than azathioprine, and does not cause bone marrow suppression in humans or animals. CsA treatment of glomerulonephritis mechanism of action has not yet been clarified. Most of the pathogenesis of nephritis is closely related to the formation of circulating immune complexes or the formation of anti-glomerular basement membrane (GBM) antibodies. CsA, as an immunosuppressive agent, selectively acts on helper T