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目的:探讨食管鳞癌组织AIB1的表达水平及其与Ki-67的相关性。方法:用免疫组织化学SP方法,联合检测20例正常食管鳞状上皮组织和60例食管鳞癌组织中AIB1和Ki-67的表达,分析AIB1的表达与临床病理参数的关系以及与Ki-67的相关性。结果:20例正常食管鳞状上皮组织中呈微弱表达或不表达,60例食管鳞癌组织中有25例(41.6%)为AIB1高表达,P<0.05。AIB1的表达水平与临床分期、淋巴结转移有明显相关性;在T3～T4期的表达水平高于T1～T2期(P<0.05),在有淋巴结转移的组织中表达较高(P<0.05),而其在不同性别、年龄、病理学分型中的表达差异无统计学意义,P>0.05;Ki-67蛋白在食管鳞状细胞癌中的表达为65.0%(39/60),在39例Ki-67蛋白阳性表达的食管鳞癌组织中有29例同时表达AIB1,且其中25例AIB1过表达,AIB1与Ki-67的表达呈中度正相关,P<0.01。结论:AIB1蛋白与食管鳞癌的临床分期和淋巴结转移有相关性,Ki-67可能也是AIB1蛋白非类固醇激素受体途径的相关蛋白之一。
Objective: To investigate the expression of AIB1 in esophageal squamous cell carcinoma and its relationship with Ki-67. Methods: The expression of AIB1 and Ki-67 in 20 cases of normal esophageal squamous epithelium and 60 cases of esophageal squamous cell carcinoma were detected by immunohistochemical SP method. The relationship between the expression of AIB1 and clinicopathological parameters was analyzed. Relevance. Results: Twenty cases of normal esophageal squamous epithelium were weakly expressed or not expressed. AIB1 was highly expressed in 25 cases (41.6%) of 60 esophageal squamous cell carcinomas, P <0.05. The expression level of AIB1 was significantly correlated with clinical stage and lymph node metastasis. The expression level of AIB1 in stage T3 ~ T4 was higher than that in stage T1 ~ T2 (P <0.05), and was higher in the tissues with lymph node metastasis (P <0.05) , While there was no significant difference in gender, age and pathological type (P> 0.05). The expression of Ki-67 in esophageal squamous cell carcinoma was 65.0% (39/60) 29 cases of Ki-67 positive esophageal squamous cell carcinoma expressed AIB1 at the same time, and 25 of them were over-expressed AIB1. There was a moderate positive correlation between AIB1 and Ki-67 (P <0.01). Conclusion: AIB1 protein is correlated with the clinical stages and lymph node metastasis of esophageal squamous cell carcinoma. Ki-67 may also be one of the related proteins of AIB1 protein non-steroid hormone receptor pathway.