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【据《Nat Commun》2015年5月报道】题:病毒性和非病毒性慢性肝脏疾病中干扰素λRS12979860基因型与肝纤维化的相关性研究(作者Eslam M等)组织纤维化是促使约45%人群死亡的关键病理学过程。组织纤维化很可能受宿主遗传结构的影响。来自悉尼大学的Eslam M等以肝脏疾病为模型进行研究,证明了IFNL4内含子区域的RS12979860多态性位点是一个强的肝纤维化预测因子,并且与病原学无关。该项研究共纳入4172位患者,包括3129位慢性丙型肝炎、555位慢性乙型肝炎患者和488位非酒精性脂肪性肝病患者;结果显示RS12979860 CC型患者有更严重
[Nat Commun, May 2015] Title: Association of Interferon λRS12979860 Genotype with Liver Fibrosis in Viral and Non-Viral Chronic Liver Diseases (by Eslam M, et al.) Tissue fibrosis is a contributing factor of about 45 % Critical pathological process of death in humans. Tissue fibrosis is likely to be affected by the genetic structure of the host. Eslam M from the University of Sydney and other liver disease as a model for the study to prove that the IFN12 intron region RS12979860 polymorphism site is a strong predictor of hepatic fibrosis and has nothing to do with the etiology. The study enrolled 4172 patients, including 3129 chronic hepatitis C, 555 patients with chronic hepatitis B and 488 patients with non-alcoholic fatty liver disease; the results showed that patients with RS12979860 CC type more serious