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目的：探讨ＡＭＩ后血中ＩＬ－６．Ｆｉｂ浓度变化及二者之间的关系。方法：将２１例患者分为溶栓组（１０例）和未溶栓组（１１例），并以３０例健康献血员为正常对照。于入院即刻（第１天）、第２、３、５、７天和第１４天抽取静脉血测定ＩＬ－６、Ｆｉｂ。结果：ＡＭＩ病人各次血清ＩＬ－６水平明显高于对照组（ｐ＜０．００１）；第３天达峰值（２０２．５±８２．１）ｎｇ／Ｌ，显著高于第１天水平（Ｐ＜０．０５）。血浆 Ｆｉｂ于第 ３天始明显高于实验室参考值（Ｐ＜０．０１）；第 ７天达峰值（４３８．１±８６．３）ｇ／ｄｌ显著高于第１天水平（Ｐ＜０．００１）。未溶栓组Ｆｉｂ峰值出现在第５天。△ＩＬ－６与△Ｆｉｂ呈直线正相关（ ｒ＝ ０．４５４，Ｐ＜０．０５）。△ＩＬ－６、△Ｆｉｂ与 ＣＫ－ＭＢ峰值无明显相关。提示： ＩＬ－６是 ＡＭＩ后促进肝脏合成 Ｆｉｂ，使血中Ｆｉｂ升高的一个重要细胞因子。
Objective: To explore the blood IL-6 after AMI. Fib concentration changes and the relationship between the two. Methods: Twenty-one patients were divided into thrombolysis group (n = 10) and no thrombolysis group (n = 11), and 30 healthy blood donors were used as normal control. Venous blood samples were taken for determination of IL-6 and Fib immediately after admission (day 1), days 2, 3, 5, 7, and 14. Results: The levels of serum IL-6 in patients with AMI were significantly higher than those in controls (p <0.001), reaching the peak on the third day (202.5 ± 82.1) ng / L, significantly higher than those on the first day P <0.05). The plasma Fib level was significantly higher than that of the laboratory at the third day (P <0.01) and reached the peak at the seventh day (438.1 ± 86.3) g / dl, significantly higher than that of the first day .001). Fib peak in the group without thrombolysis appeared on the 5th day. There was a linear positive correlation between IL-6 and △ Fib (r = 0.454, P <0.05). △ IL-6, △ Fib and CK-MB peak no significant correlation. It is suggested that IL-6 is an important cytokine that promotes Fib synthesis in the liver and increases Fib in the blood after AMI.