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目的分析位于直肠的胃肠道间质瘤(gastrointestinal stromal tumors,GIST)的临床特征、治疗效果及其影响因素。方法对32例直肠GIST临床资料复核并加以随访进行回顾分析。结果全组1、2、4年生存率分别为100%、92.6%和84.0%,扩大切除术组与局部切除组患者生存率差异无显著性(P>0.05)。术后复发及远处转移患者口服伊马替尼治疗有效。结论直肠GIST仍以外科治疗为主,其手术方式的选择更多取决于肿瘤的部位和大小,原则上施行局部完全切除即可,广泛切除或扩大淋巴结清扫不能提高生存率,伊马替尼可改善患者预后。
Objective To analyze the clinical characteristics, therapeutic effects and influencing factors of gastrointestinal stromal tumors (GIST) in the rectum. Methods 32 cases of rectal GIST clinical data were reviewed and followed up for review. Results The overall 1-, 2-, and 4-year survival rates were 100%, 92.6%, and 84.0%, respectively. There was no significant difference in the survival rate between the extended resection group and the local resection group (P>0.05). Patients with postoperative recurrence and distant metastasis were treated with oral imatinib. Conclusions Rectal GIST is still dominated by surgical treatment. The choice of surgical approach depends more on the location and size of the tumor. In principle, local complete resection can be performed. Extensive resection or enlarged lymph node dissection does not improve survival. Imatinib can improve the survival rate. Improve patient prognosis.