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目的探讨放射治疗结合动脉灌注化疗治疗中、晚期食管癌的临床应用价值。方法对38例中、晚期食管癌患者随机分组为单纯放疗组和放射治疗加化疗综合治疗组并随访3～24个月,观察临床及放射学改善情况,评价治疗效果。结果治疗后大部分患者临床指标及X线片表现明显改善,综合治疗组X线Ⅰ级片率明显高于单纯放疗组。结论放射治疗结合经导管直接向肿瘤供血动脉灌注化疗药物,能增加局部的药物浓度和药物效应,减轻全身毒性反应,有效缩小局部肿块。因此,采用放射治疗结合超选择性食管供血动脉灌注化疗是一种行之有效的综合治疗中、晚期食管癌的方法。
Objective To investigate the clinical value of radiotherapy combined with arterial infusion chemotherapy in the treatment of advanced esophageal cancer. Methods 38 cases of advanced esophageal cancer patients were randomly divided into radiotherapy group and radiotherapy plus chemotherapy combined treatment group and followed up for 3 to 24 months to observe the clinical and radiological improvement and evaluate the therapeutic effect. Results The clinical manifestations and X-ray manifestations of most patients after treatment were significantly improved. The X-ray I grade of the comprehensive treatment group was significantly higher than that of the radiotherapy alone group. Conclusion Radiotherapy combined with transcatheter injection of chemotherapeutic drugs directly into tumor feeding artery can increase local drug concentration and drug effect, reduce systemic toxicity and effectively reduce local mass. Therefore, the use of radiotherapy combined with super-selective esophageal artery infusion chemotherapy is an effective method of comprehensive treatment of advanced esophageal cancer.