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目的探讨血液IL-33联合PCT表达对哮喘儿童诊断和治疗的应用价值。方法回顾性分析2014年12月-2015年12月住院支气管哮喘急性发作和稳定期患儿各60例,比较哮喘不同分期、不同分级、不同疗效血液中IL-33和PCT水平。结果急性发作组IL-33和PCT浓度高于缓解组,差异有统计学意义(t值分别为10.52、4.12,P<0.01);随着哮喘分级增加,血液中IL-33浓度显著升高;血液中IL-33水平与哮喘分级呈正相关(r=0.69,P<0.01);不同临床疗效IL-33差异有统计学意义(F=29.22,P<0.01);血液中PCT与哮喘分级、疗效无显著相关(P>0.05)。结论血液中IL-33浓度能反映哮喘严重程度及疗效,血液PCT浓度可作为哮喘伴细菌感染的重要依据。
Objective To investigate the value of blood IL-33 combined with PCT expression in the diagnosis and treatment of asthmatic children. Methods The clinical data of 60 children with acute bronchial asthma exacerbation and stable from December 2014 to December 2015 were retrospectively analyzed. The levels of IL-33 and PCT in different stages, grades and curative effects of asthma were compared. Results The concentrations of IL-33 and PCT in the acute attack group were significantly higher than those in the remission group (t = 10.52, 4.12, respectively, P <0.01). With the increase of asthma classification, the concentration of IL-33 in the blood increased significantly The level of IL-33 in blood was positively correlated with the grade of asthma (r = 0.69, P <0.01). The difference of IL-33 in different clinical efficacy was statistically significant (F = 29.22, P <0.01) No significant correlation (P> 0.05). Conclusion The concentration of IL-33 in blood can reflect the severity and efficacy of asthma. The concentration of PCT in blood can be used as an important basis for asthma with bacterial infection.