1病例患者男45岁,结婚4年,其妻未孕。因性功能障碍,排精困难,而不能同房,导致不育,故到本院就诊。经精液检查未见异常。夫妇身体健康,非近亲婚配,表型智力均正常,否认有家族遗传病史。第二性征、外生殖器发育良好。妻子妇科检查正常。患者双方的父母非近亲结婚, 1 case patients male 45 years old, married 4 years, his wife is not pregnant. Due to sexual dysfunction, ejaculation difficulties, but not the same room, leading to infertility, so to our hospital. No abnormalities were detected by semen examination. Couples healthy, non-relatives marriage, phenotypic intelligence are normal, deny a family history of genetic disease. Second character, external genital development well. Wife gynecological examination was normal. Both parents of patients marry non-relatives,