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目的探讨超声异常孕妇在B超引导下的经皮脐静脉穿刺术在中晚期产前诊断中的安全性及应用价值。方法回顾性分析我院产前诊断中心2013年1月至2013年12月超声异常孕妇在B超引导下的经皮脐静脉穿刺病例120例,对脐血细胞染色体产前诊断结果及相关并发症进行分析。结果发现异常核型13例,异常核型检出率10.83%,其中数目异常11例,结构异常2例,术后无胎儿发生流产,无感染、羊水栓塞、胎盘早剥、胎膜早破、胎死宫内的发生。结论血清学筛查有一定的漏诊率,对未做血清学筛查的孕妇和血清学筛查低风险孕妇进行超声筛查是产前筛查的重要和必要手段,超声异常孕妇在超声引导下行经皮脐静脉穿刺技术是安全可靠的中晚期产前诊断取材技术,可以有效的降低出生缺陷人数,提高人口素质。
Objective To investigate the safety and application value of percutaneous umbilical vein puncture guided by ultrasound in pregnant women with abnormal ultrasound in the diagnosis of advanced prenatal period. Methods A retrospective analysis of 120 cases of transvaginal umbilical venipuncture in pregnant women with ultrasound abnormalities from January 2013 to December 2013 in our hospital from January 2013 to December 2013 was carried out. Prenatal diagnosis of umbilical cord blood cells and related complications were performed analysis. The results showed that abnormal karyotype in 13 cases, abnormal karyotype detection rate of 10.83%, of which 11 cases were abnormal, 2 cases of structural abnormalities, no fetal miscarriage, no infection, amniotic fluid embolism, placental abruption, premature rupture of membranes, The occurrence of fetal death. Conclusion Serological screening has a certain misdiagnosis rate. It is an important and necessary measure for prenatal screening for pregnant women who have not done serological screening and low risk pregnant women for serological screening. Ultrasound-guided pregnant women Percutaneous umbilical vein puncture is a safe and reliable technique for early diagnosis of prenatal diagnosis, which can effectively reduce the number of birth defects and improve the quality of the population.